Are you tired of seeing more hair in your brush and less on your scalp? Maybe you've already tried Finasteride, but continue to still go thin?
Hair loss can be a distressing experience, but the good news is that there are effective treatments available to help you keep hold of your luscious locks, and in some patients... regrow it.
Two popular options for treating hair loss are Finasteride and Dutasteride. In this blog, we'll explore what Dutasteride is, how it works, and compare it to its well-known counterpart, Finasteride.
What is Dutasteride? Dutasteride is an FDA-approved medication primarily used to treat benign prostatic hyperplasia (BPH), a condition where the prostate gland enlarges and causes urinary problems in men. Several years ago, men taking Finasteride for BPH started to report that their hair was growing back and since then Finasteride and Dutasteride have been used to help treat male pattern hair loss.
It is also important to note that, Dutasteride is not licensed to be used for hair loss in the UK and therefore, when used, it is used 'off label'. Finasteride is the only DHT blocking medication in the UK that has a licence to be used to treat hair loss.
How Does Dutasteride Work?
Dutasteride belongs to a class of medications known as 5-alpha-reductase inhibitors. This also includes Finasteride. The key to understanding how Dutasteride works lies on its impact on dihydrotestosterone (DHT), a hormone that plays a significant role in hair loss.
Why do men loose their hair?
In individuals genetically predisposed to male pattern baldness, DHT has been identified as a major contributor. DHT attaches itself to receptors on the hair follicles on top of your head, and over time causes miniaturisation of these hair follicles, leading to a gradual reduction in hair density and thickness, and in some cases total loss of hair.
How can Finasteride and Dutasteride help?
Inhibition of 5-alpha-reductase: Both Dutasteride and Finasteride work by inhibiting the enzyme 5-alpha-reductase. This enzyme is responsible for converting testosterone into DHT. Finasteride works by blocking type 2, and Dutasteride works by blocking both type 1 and type 2 (which is why Dutasteride is thought to be more powerful). By blocking the conversion of testosterone to DHT, these medications reduce the levels of DHT in the scalp, which in turn can result in hair regrowth and increased hair thickness. This is the primary mechanism behind the effectiveness of both Dutasteride and Finasteride.
Dutasteride vs. Finasteride: A Comparison
Efficacy: Studies suggest that Dutasteride may be more effective in reducing DHT levels compared to Finasteride. This is why it is commonly used as a 'step-up' treatment for men who have continued to notice hair loss whilst taking Finasteride for at least 6 months. However, with increased potency comes an increased risk of side effects.
Side Effects: While both medications are generally well-tolerated, Dutasteride is associated with a higher risk of side effects, such as; low mood, low energy levels, low sex drive and some men have reported in inability to achieve/maintain an erection. It's essential to discuss any worries about these potential side effects with your healthcare provider.
Half Life: This measurement refers to how long it takes your body to eliminate 50% of the drug. The tissue half life of Finasteride is 5-6 days, whilst the half life of Dutasteride is 5 weeks. Which leads us on nicely to our next point...
Dosage: Finasteride is typically taken once a day (as a 1mg tablet) or can be sprayed onto the scalp twice a day if used in a liquid form. Dutasteride on the other hand, may be used much less frequently, this varies and usually depends on your doctor's recommendation.
Why would I want to inject Dutasteride into my scalp?
Reduced Frequency: Studies have found that just one treatment, every 3 months is enough to see positive results. No more remembering to take a tablet everyday, or having to use the spray version every morning and night, not to mention the annoyance of your hair looking greasy after you've just washed it, because you had to apply your spray.
Localised Treatment: Injecting the medication at the level of the hair follicles in the scalp where it is needed, reduces the body's systemic uptake of the drug. Studies have also shown that scalp injections did not lower serum (blood) testosterone levels, which is probably one of the reasons why no side sexual side effects were reported in the study group.
Continued to notice hair loss? If you have been using Finasteride/Dutasteride medication and have continued to notice your hair is thinning, or you have experienced side effects, then you might want to try Dutasteride injections.
Treatment Protocol
We recommend one treatment, every months.
If you have PRP every 6 or 12 months, we can combine these two treatments for even better results.
Cost
Dutasteride Mesotherapy £100
PRP + Dutasteride £350
Conclusion
Dutasteride and Finasteride are both valuable medications in the fight against hair loss, offering hope to men wanting to restore their hair and confidence. However, the choice between the two should be made in consultation with a healthcare professional. Consider factors such as effectiveness, side effects, availability, and personal preferences to determine which medication is the best fit for you. Remember that results may take 3-6 months to become noticeable, and consistent use is crucial to maintain any progress.
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